A groundbreaking study from researchers at the University of British Columbia (UBC) has identified an inherited genetic mutation that may increase the risk of developing aggressive prostate cancer at a younger age. The discovery focuses on mutations in a gene called CDK12, which researchers say should be considered for inclusion in standard genetic testing panels for people with hereditary prostate cancer risk.
For families affected by prostate cancer, this research highlights an important message: understanding your genetic risk can help identify cancer earlier, when treatment options may be more effective.
What Is CDK12 and Why Does It Matter?
The CDK12 gene plays an important role in helping cells repair damaged DNA. When this gene stops functioning properly, cells may accumulate genetic changes that can contribute to cancer development.
Researchers previously believed that CDK12 mutations found in prostate cancer were mainly somatic mutations, meaning they developed only within the tumour and were not inherited. This new study suggests that, in some cases, CDK12 mutations can be inherited, meaning they can be passed through families.
Study Finds Inherited CDK12 Mutations Linked to Aggressive Prostate Cancer
Researchers from UBC and international institutions analysed genetic data from 4,535 patients with aggressive prostate cancer, drawn from Canada, the United States, Australia, Europe and other regions. They identified five unrelated men who carried inherited CDK12 mutations.
Key findings:
- All five men developed metastatic prostate cancer
- Diagnosis occurred between ages 44 and 62
- Some patients also developed additional CDK12 changes within their tumours
- Family histories showed possible links to additional prostate and ovarian cancers
Researchers used a unique genetic pattern left behind by inactive CDK12 genes to confirm that the inherited mutation played a direct role in tumour development.
Why This Discovery Matters for Families
Although inherited CDK12 mutations appear to be rare, researchers believe they may affect hundreds of families worldwide. For families carrying this mutation, identifying the risk earlier could allow earlier cancer screening, more personalized monitoring plans, genetic counselling for relatives, and earlier intervention before cancer spreads.
Dr. Alexander Wyatt, senior author of the study, emphasized that identifying these families earlier could provide opportunities for enhanced screening while curative treatment options are still available.
Genetic Testing Is Changing Cancer Prevention
Cancer care is increasingly moving toward precision medicine, where prevention, screening and treatment decisions are guided by a person’s individual genetic information. Today, genetic testing may help identify inherited risks associated with several cancers, including prostate, breast, ovarian, and colorectal cancer, along with other hereditary cancer syndromes.
If multiple family members have had cancer, especially cancers occurring at younger ages, discussing genetic counselling with a healthcare professional may be appropriate.
What Men Should Know About Prostate Cancer Risk
Many prostate cancers develop slowly, but some forms can be aggressive. Men should discuss prostate cancer screening with their healthcare provider, especially if they have a father, brother or close relative with prostate cancer, multiple family members affected by cancer, a history of cancers occurring at younger ages, or concerns about inherited cancer risk.
Early conversations can help determine whether PSA testing, genetic counselling or additional screening may be appropriate.
Centrum Pharmacy: Supporting Preventive Healthcare in Our Community
At Centrum Pharmacy, we believe healthcare is not only about treating illness — it is about identifying risks early and helping patients make informed decisions. Our pharmacists work alongside patients and healthcare providers by supporting medication management, chronic disease prevention, health education, vaccination services, and referrals and healthcare navigation.
If you have concerns about your family history of cancer or want to better understand your health risks, speak with your healthcare provider or pharmacist. Knowledge, prevention and early detection can save lives.
Source: research conducted by investigators from the University of British Columbia and international cancer research institutions.
Looking for a Family Doctor?
Check our get a doctor page to see if our waitlists are open and consider transferring your prescriptions to Centrum Pharmacy!
Come for the Convenience, Stay for the Service.
Caring for Your Family Since 1999
Disclaimer: The medical information on this site is provided as an information resource only and is not to be used or relied on for any diagnostic or treatment purposes. This information does not substitute for professional diagnosis and treatment. Please do not initiate, modify, or discontinue any treatment, medication, or supplement solely based on this information. Always seek the advice of your healthcare provider first. Full Disclaimer.
