GLP-1 Agonist Medications: What Patients in Ontario Should Know

GLP-1 agonist medications have become an important option in the treatment of obesity, diabetes, and metabolic health. In recent years, growing awareness, new research, and changes in medication availability have raised many questions for patients considering or already using these therapies.

This page provides a clear, evidence-based overview of GLP-1 agonist medications, how they work, and what patients in Ontario should know when navigating treatment options.

What Are GLP-1 Agonist Medications?

GLP-1 agonists (glucagon-like peptide-1 receptor agonists) are prescription medications that mimic a naturally occurring hormone involved in appetite regulation and blood sugar control.

They work by:

• Increasing feelings of fullness
• Reducing appetite and food intake
• Slowing gastric emptying
• Improving insulin response and blood sugar regulation
  

Because of these effects, GLP-1 agonist medications are commonly prescribed for type 2 diabetes, medical weight management, or both.

Common GLP-1 Medications Patients May Hear About

Several GLP-1 medications are currently used in Canada, including:

• Ozempic (semaglutide)
• Wegovy (semaglutide for weight management)
• Saxenda (liraglutide)
• Mounjaro (tirzepatide)
  

Each medication differs in:

• Approved indications
• Dosing schedules
• Expected benefits
• Side-effect profiles
• Insurance coverage and availability
  

Your healthcare provider can help determine which option may be appropriate based on your individual health needs.

Important Updates on Saxenda® Availability

Patients currently using Saxenda® should be aware that its manufacturer has announced a planned discontinuation of production and commercial availability as of March 2026. This decision is not related to safety or quality concerns.

Additionally, a shortage of Saxenda® in Canada is expected as early as October 2025, or sooner. Patients using Saxenda are encouraged to plan ahead and discuss alternative GLP-1 options with their healthcare team.

👉 Learn more: Saxenda Discontinuation Notice: What You Need to Know

Effectiveness, Safety, and Ongoing Research

Research into GLP-1 medications continues to expand beyond weight loss and diabetes management. Emerging studies are exploring potential roles in areas such as:

• Brain health and neuroprotection
• Cardiovascular risk reduction
• Cancer risk modulation
• Fertility and reproductive health
  

While some findings are promising, not all benefits are fully established, and research is ongoing.

👉 Related reading:

• Could GLP-1 Drugs Protect the Brain?
• Could Weight-Loss Medications Like Wegovy and Ozempic Help Prevent Cancer?
• The Rise of “Ozempic Babies”

Adherence, Side Effects, and Long-Term Use

Success with GLP-1 therapy depends on more than simply starting a medication. Patients may experience side effects such as nausea, gastrointestinal discomfort, or appetite changes, particularly during dose escalation.

Long-term success often depends on:

• Proper dosing and titration
• Ongoing monitoring
• Nutrition and lifestyle support
• Consistent access to medication
  

👉 Learn more about adherence and pharmacist support:

• The GLP-1 Adherence Challenge: How Your Pharmacist Supports Success
  

Safety Concerns and Online Risks

As demand for GLP-1 medications has grown, so have concerns about:

• Unauthorized or counterfeit products
• Online-only prescribing services
• Inappropriate medication switching
• Insurance-driven patient steering
  

Patients should be cautious when seeking GLP-1 medications online and ensure they are receiving care from licensed healthcare professionals.

👉 Learn more:

• Thinking About Buying GLP-1 Drugs Like Ozempic or Mounjaro? Beware of Fake or Unauthorized Products
• Beyond the Buzz: A Closer Look at Online Ozempic Prescriptions
• Patient Steering and GLP-1 Medications — A Dangerous Combination

How a Pharmacist Can Support Your GLP-1 Treatment

Pharmacists play an important role in supporting patients using GLP-1 medications by:

• Reviewing current therapy
• Monitoring side effects and adherence
• Coordinating with prescribers
• Providing education during transitions between medications
  

This support is especially important during times of medication shortages or discontinuations.

Final Thoughts

GLP-1 agonist medications continue to evolve, offering new opportunities — and new challenges — for patients managing weight and metabolic health. Staying informed, planning ahead, and working closely with your healthcare team can help ensure safe, effective, and uninterrupted care.

For patients currently using or considering GLP-1 therapy, education and proactive planning are key.