Antidepressants are a vital part of treatment for depression, anxiety, PTSD, and chronic pain—conditions that affect millions of Canadians. However, one of the most common and frustrating side effects of many antidepressants is weight gain, which can affect adherence to treatment and long-term health.
At Centrum Pharmacy, we understand how concerning this side effect can be. That’s why our pharmacists are well-informed about the latest research and equipped to help you manage and minimize antidepressant-related weight changes—without compromising your mental health treatment.
What the Latest Research Shows
A large study examining over 180,000 patients between 2010 and 2019 found that some antidepressants are more likely to cause weight gain than others:
- More likely to cause weight gain:
- Escitalopram (+0.41 kg)
- Paroxetine (+0.37 kg)
- Duloxetine (+0.34 kg)
- Venlafaxine (+0.17 kg)
- Citalopram (+0.12 kg)
- Weight neutral or associated with weight loss:
- Fluoxetine (similar to sertraline)
- Bupropion (–0.22 kg) — also showed the highest adherence rate at 6 months
This means that choosing the right antidepressant could help minimize unwanted weight gain.
How Centrum Pharmacists Can Help
Our pharmacists work closely with your healthcare provider to:
- Review your current medications and health goals – especially if you’re concerned about weight or metabolic issues.
- Advocate for alternatives when clinically appropriate.
- Monitor and support adherence, which improves long-term outcomes.
- Offer personalized lifestyle strategies that complement your treatment.
- Suggest Pharmaceutical therapy to reduce weight gain
Strategies to Manage Antidepressant-Related Weight Gain
If switching medications isn’t an option, there are still effective ways to manage your weight:
- Nutritional Support
- Eat more whole, unprocessed foods.
- Reduce sugar and refined carbs.
- Watch portion sizes and avoid emotional eating triggers.
- Exercise Regularly
- Incorporate at least 150 minutes of moderate activity per week (e.g., walking, cycling, swimming).
- Resistance training helps build lean muscle and boost metabolism.
- Try Time-Restricted Eating
- Limiting food intake to an 8–12 hour window during the day may help with weight management.
- Improve Sleep
- Poor sleep can increase appetite and cravings—especially for high-calorie foods.
- Track Progress
- Use a journal or app to track food, mood, weight, and physical activity.
Talk to Us
Your health is our priority. If you’re starting an antidepressant or have noticed weight changes, book a one-on-one medication consultation with a Centrum Pharmacist. We’ll help you understand your treatment and take steps to support both your mental and physical well-being.
Ask us today about strategies to manage antidepressant-related weight gain. You’re not alone—and we can help.
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Disclaimer: The medical information on this site is provided as an information resource only and is not to be used or relied on for any diagnostic or treatment purposes. This information does not substitute for professional diagnosis and treatment. Please do not initiate, modify, or discontinue any treatment, medication, or supplement solely based on this information. Always seek the advice of your healthcare provider first. Full Disclaimer.
